Yes: Yes, this is perfectly safe. Oxycodone is often combined with acetaminophen or aspirin in the same pill (as Percocet or Percodan) and can be taken at the same time as ibuprofen. Combining oxycodone with non-narcotic pain relievers can enhance its effectiveness so you do not need to take as much or take it as often.
Answered 4/24/2015
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