A 40 yr old male with testosterone & cortisol deficiences oestradiol level is 665 (ref: 10-40 pg/ml) could pituitary adenoma increase male oestrogen?

Perhaps: You have real issues with the estrogen level that you are walking around with, you are at very high risk of stroke and heart attack. Yes, a pituitary tumors, such as a prolactinoma is a very strong possiblity. If you have not already done so, you need to see endocrinologist and you need an MRI of your brain to check your pituitary gland.