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A 33-year-old female asked:

I am currently on wellbutrin (bupropion) xl and lexapro and was prescribed tramadol. wanted to see if there was a bad interaction if taken together?

2 doctor answers5 doctors weighed in
Dr. Yash Khanna
Family Medicine 59 years experience
YesThereIsInteractio: Yes taking Tramadol with these two increases the risk of seizures which may occur with either of them
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Bahman Omrani
Pain Management 19 years experience
Requires Tact: Combination of SSRI such as Lexapro can apparently cause serotonin syndrome. In addition, the manufacturer of tramadol notes concomitant therapy with SSRI increases risk of seizures.Furthermore, both Tramadol and Wellbutrin (bupropion) can lower the seizure threshold. PGT testing to determine CYP2D6 status may be able to guide treatment. The prescribing physician(s) should be informed of this combination.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Feb 25, 2023
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