Yes. 25 mg/kg/day : of Chloral Hydrate given long-term can ^ risk of central sleep apnea from CNS depression, obstructive sleep apnea from respiratory depression, aspiration pneumonia if given on a full stomach, diarrhea & vomiting if not given with a full glass of water, adverse interactions with anti-epileptics like phenobarbital & some other meds, liver & kidney damage, drug dependence, etc. Please see comment.
Answered 3/17/2015
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