Can i take sleep-eze 25mg diphenhydramine hydrochloride tablets while on 50 mg sertraline, but in a couple days its going up to 100mg. but is it safe? just until my next appointment with my psychiatrist?

While Benadryl and Sertraline can both individually cause CNS depression, both taken together are safe and have no adverse drug reactions. Continued Advised caution with operating vehicles and heavy machinery

It is not often but it can occur that the combination of diphenhydramine hydrochloride and sertraline can cause what is called Serotonin Syndrome which can have symptoms of shivering, diarrhea, rigid muscles, fever and seisures and even death. It is rare but it can occur. Therefore, it would be best to avoid combining those two medications. Good question to ask!