A member asked:

I take sertraline hcl 50 mg and trazodone 150 mg is it ok to take benadryl (diphenhydramine) allergy liqui-gels 25 mg with the other meds?

9 doctors weighed in across 3 answers
Dr. Krishna Kumar answered

Specializes in Psychiatry

Sertraline,Trazodone: Sertraline is a medication for depression in SSRI group. Trazodone is a medication for depression in Tricyclic group. It can have cardiac side effects including Bundle Branch Block. Both medications can affect sleep. Trazodone is more likely to give sleep. Benadryl is a medication for Allergy. It is not a Sleep medication. See a psychiatrist and a cardiologist for side effects and cardiac status

Answered 5/1/2016

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Dr. Al Hegab answered

Specializes in Allergy and Immunology

Be cautious: Benadryl (diphenhydramine) would interact with trazodone causing CNS depression

Answered 12/21/2020

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Dr. John Moranville answered

Specializes in Psychiatry

For what?: All meds have potential adverse effects and the more meds you are on increases this risk. Both sertraline and trazodone are antidepressants, but you are likely taking trazodone for sleep and these 2 are not an uncommon combo. Benadryl (diphenhydramine) is also sedating. If you need Benadryl (diphenhydramine) for allergies talk to your doc about tapering down trazodone. Also consider seeing an allergist

Answered 12/21/2018

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