Sertraline,Trazodone: Sertraline is a medication for depression in SSRI group. Trazodone is a medication for depression in Tricyclic group. It can have cardiac side effects including Bundle Branch Block. Both medications can affect sleep. Trazodone is more likely to give sleep. Benadryl is a medication for Allergy. It is not a Sleep medication. See a psychiatrist and a cardiologist for side effects and cardiac status
Answered 5/1/2016
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Be cautious: Benadryl (diphenhydramine) would interact with trazodone causing CNS depression
Answered 12/21/2020
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For what?: All meds have potential adverse effects and the more meds you are on increases this risk. Both sertraline and trazodone are antidepressants, but you are likely taking trazodone for sleep and these 2 are not an uncommon combo. Benadryl (diphenhydramine) is also sedating. If you need Benadryl (diphenhydramine) for allergies talk to your doc about tapering down trazodone. Also consider seeing an allergist
Answered 12/21/2018
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