Is lyrica (pregabalin) and cannabis a good combo for chronic pain ?

No: Depending on where you live, for non cancer pain-Cannabis may STILL be illegal even for medicinal purposes. In my opinion, unless if it can be delivered in different way, the SMOKE would cause way too much airway inflammation and put users at risk for COPD. Lyrica (pregabalin) is a proven safe, and great for chronic pain depending on cause.