What's the difference between hodgkin's lymphoma and non-hodgkin's lymphoma?

Different lymphomas: There are around 30 different types of lymphoma distinguished by how they look under the microscope, the proteins they bear on their cell surface, and the gene mutations that caused the problem to begin with. The type of treatment varies a lot between the different types and is too complicated to cover here. The Leukemia and Lymphoma Society of America website will be your best bet for more details.

Probably a lot: But the biggies are reed-sternberg cells define hd, not found in nhl. Most nhl's are b-cell, where hd is not. Hd spreads contiguously, nhl does not. Both treated with chemo, different kinds, and rituxumab is the new targeted therapy for b-cells, with chemo or conjugated with radio-isotopes.