A member asked:

Tried ssri/xanax for depression/anxiety, bad reactions. i heard wellbutrin (bupropion) works on different brain chemicals than ssri's. can wellbutrin (bupropion) help?

2 doctors weighed in across 2 answers
Dr. John Gaffney answered

Specializes in Psychiatry

Wellbutrin (bupropion): Wellbutrin does work on different neurotransmitters than SSRI's - specifically norepinephrine and dopamine. That said, you mentioned using Xanax (alprazolam) in the past - and Wellbutrin does have an "activating" effect for many people. So, it's probably not the best option for you. I'd suggest seeing a psychiatrist to talk over all of the options available (sometimes dosing is the key). Good luck!

Answered 1/26/2015


Dr. Judith Tellerman answered

Specializes in Clinical Psychology

DEPRESSION: Antidepressants help but may not be enough because they do not teach you coping mechanisms. Psychotherapy with a Clinical Psychologist with expertise in multiple types of psychotherapy can help your medications to work better. Best to discuss medication with a Psychiatrist. If not comfortable with your Dr. see another for a second opinion & have a physical exam to rule out illness.

Answered 1/14/2021



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