Multiple transmitter: Pain is complicated and multiple neurotransmitters modulate pain. Not to confuse you but they include substance P, norepinephrine, VIP, endorphins, serotonin, somatostatin, CGRP, GABA, glutamate, cholecystokinin, and nitric oxide and there are just as many, if not more, receptors. As you can see, the regulation of pain is very complex with multiple etiologies.
Answered 11/28/2017
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