A member asked:

What neurotransmitters are released by opioid usage?

A doctor has provided 1 answer
Dr. Paul Grin answered

Specializes in Pain Management

Endorphins: Because C-fibers release several excitatory neurotransmitters (e.g., substance P. CGRP), activation of opioid receptors will reduce the release of these transmitters from the presynaptic terminals of afferent sensory neurons. The opioids peptides that occur naturally in the human body are endorphins.

Answered 11/30/2014

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