A member asked:

This is my 15th day of 15 day treatment w/bactrim for sinus infection. 15 min. after taking next to last pill in bottle, got hives. related?

A doctor has provided 1 answer

Possible allergy: If a person is allergic to a medication, it may take repeated exposure to the drug before the development of the allergic symptom or sign, for example, itching, hives or rash. So getting hives on the last day of Bactrim (sulfamethoxazole and trimethoprim) therapy is suggestive of allergy to the medication. Please inform your health care provider of this reaction.

Answered 10/17/2018

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