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A 35-year-old female asked:

if you're suffering from major depression, would amphetamines work. if not, what would it do instead of working?

1 doctor answer1 doctor weighed in
Dr. Pamela Pappas
Psychiatry 42 years experience
Not by themselves: Ritalin (methylphenidate) has sometimes been given to augment antidepressants in treatment-resistant depression, but amphetamines do not reliably treat depression by themselves. Used alone, any lightening of mood would have a daily wear-off effect. Also there could be increased tension, irritability, and jitteriness -- not pleasant for someone who already has an agitated-type depression.

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Last updated Jul 1, 2014
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