Not by themselves: Ritalin (methylphenidate) has sometimes been given to augment antidepressants in treatment-resistant depression, but amphetamines do not reliably treat depression by themselves. Used alone, any lightening of mood would have a daily wear-off effect. Also there could be increased tension, irritability, and jitteriness -- not pleasant for someone who already has an agitated-type depression.
Answered 7/1/2014
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