A member asked:

In blood work, does elevated gamma globulin (m-spike) often cause the total serum globulin to be elevated as well?

2 doctors weighed in across 2 answers

Yes.: If it is elevated and you have had a serum electrophoresis, urine electrophoresis, as well as kappa and lambda free chain studies performed, then i would advise consultation with a hematologist.

Answered 3/21/2013

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Dr. Veeraish Chauhan answered

Specializes in Nephrology and Dialysis

Tt could: Since, total globulin level usually includes all kinds of globulins (alpha, m spike etc). An immunoelectrophoresis can further characterize the m spike.

Answered 9/21/2013

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