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A 39-year-old member asked:

Can i take xtra strength excedrin w/30 mg of cymbalta; i read abt potential flags, can't discern risk?

4 doctor answers13 doctors weighed in
Dr. Eric Anderson
Psychiatry 21 years experience
Excedrin & Cymbalta (duloxetine): Routine use of both of these medications increases the risk of bleeding. Es Excedrin has caffeine in it, which may increase serum levels of Cymbalta (duloxetine) (including its potential side effects). The two together can also impair metabolism in the liver. That being said, occasional use of ex Excedrin is unlikely to causes problems. The key word is occasional! ultimately, check with your doctor first.
Dr. David Rosenfeld
Pain Management 27 years experience
Some risk: The combo may increase the risk of bleeding, the risk of an excess Cymbalta (duloxetine) level, and the extend of platelet inhibition.
Dr. Susan Uhrich
Psychiatry 36 years experience
The risk: Is small, but the combo can increase bleeding. Watch for unexplained bruising.
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Excedrin/Cymbalta: Only as needed & as prescribed. Long-term regular use can affect your blood clotting mechanism & increase bleeding tendencies.

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Last updated Feb 2, 2018

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