A 45-year-old female asked:
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i was prescribed biaxin (clarithromycin) for a sinus infection. i take klonopin at night to sleep. is it safe to take these medications together?

2 doctor answers
Dr. Michael Fisher
31 years experience Dermatology
Drug Interaction: Use alternative or consider lower Klonopin (clonazepam) dose. Combo may increase Klonopin (clonazepam) levels, risk of CNS depression, psychomotor impairment (hepatic metab. Inhibited). This information is from epocrates a medical app.
Answered on Oct 9, 2018
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Dr. Jason Black
24 years experience Internal Medicine
Interaction: There can be an interaction between these two medications, whereby biaxin (clarithromycin) can increase Klonopin levels. This could cause an increased effect of the Klonopin on the central nervous system. It may be prudent to consult with your physician to see about holding off on the Klonopin while taking the biaxin (clarithromycin), or possibly using a different antibiotic.
Answered on Apr 7, 2017
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