Can "high estradiol" be a side effect of spironolacton? i took 50 mg for 2 years. how long does it take to come back to normal after stop takeing it?

Very complicated: Spironolactone is a blood pressure medicine, but it also blocks a certain testosterone receptor in the skin. So gyns often use it to help with acne or excessive hair growth. It is possible your "high estrogen could be due to the underlying hormonal problem that led to the need to take spironolactone, but not to the spironolactone itself. You should discuss with with your gyn.