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Annapolis, MD
A 21-year-old female asked:

Is vyvanse and wellbutrin (bupropion) xl combo effective for treating adhd (primarily inattentive) and major depression? could this combo lower seizure threshold?

3 doctor answers8 doctors weighed in
Dr. Arman Danielyan
Child Psychiatry 29 years experience
ADHD and depression: Yes and yes. Vyvanse is highly effective for treatment of adhd, and wellbutrin (bupropion) xl for depression. The risk of seizure goes up, especially if you discontinue the medications abruptly.
Dr. Samuel Miles
Psychiatry 47 years experience
Yes and yes: Both vyvanse and wellbutrin (bupropion) can be beneficial for add. Wellbutrin (bupropion) is also an effective antidepressant. Both drugs may lower the seizure threshold. To minimize risk, maintain adequate nutrition and hydration, and avoid alcohol.
Dr. Travis Hansen
Child Psychiatry 21 years experience
Yes and Yes...: Vyvanse is an excellent medication for adhd just as wellbutrin (bupropion) is and excellent medication for depression. Wellbutrin (bupropion) can be assoicated with seizures and should not be prescribed to those with a seizure disorder or lowered seizure threshold.

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Last updated Jul 13, 2017

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