A 24-year-old female asked:
i am on the methadone program. does milk thistle supplement make methadone stronger and last longer?
2 doctor answers
Dr. Morton Levitt answered
48 years experience Pathology
Milk Thistle Effects: In some studies researchers found that relatively small concentrations of milk thistle did significantly slow down the activity of the liver enzyme cyp3a4 by 50% to 100%. This enzyme system is the essential force that metabolizes most drugs ingested, and by decreasing the system you increase the effective levels of the drug in your system. This can be very dangerous and i would be very cautious.
Answered on Jul 14, 2020
Dr. Darrell Herrington answered
33 years experience Family Medicine
No: And don't take any supplements, herbs, or over-the-counter medications without first consulting your physician. Methadone is a highly controlled substance, and you should not be experimenting with anything else. Don't take any non-physician advice or suggestions.
Answered on Jun 28, 2014
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