A member asked:

How does ionizing radiation increase the chance of meningiomas even long after the initial exposure?

2 doctors weighed in across 2 answers
Dr. Jefferson Chen answered

Specializes in Neurosurgery

Mutations: Ionizing radiation such as used in the past for tinea capitis (ringworm of the scalp) has been shown to have an increased incidence of meningiomas. It is believed that mutations were induced in the dna of the meningeal cells that ultimately lead to the development of the meningioma. As these are benign tumors that usually grow slowly, their detection is often years after the initial exposure.

Answered 2/2/2013


Dr. Jeffrey Buchsbaum answered

Specializes in Radiation Oncology

It is about latency: The cells that make a meningioma happen can really take years and years to decide to intiiate a reaction and form a meningioma. In theory, it could be just one cell. And in theory, other events may be needed to happen - events that can take a long time to randomly happen. Ir sort of winds up the old stopwatch. Something else might have to push the button. It potentiates things.

Answered 11/25/2013



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