Is paracetamol more toxic to the liver than opiates?

A Tough Comparison..: (1) tylenol (acetaminophen) (paracetamol) is a direct liver toxin and had been a leading cause of acute liver failure in the U.S. & britain. (2) opiods, rarely, may cause idiosyncratic liver toxicity (a different mechanism) that may require relatively higher doses. Neither drug should be taken in excess of routine dosing guidelines.