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A member asked:
What happens to the plasma membrane of the red blood cells of humans with liver disease to cause the formation of acanthocytes? thank you.
3 doctors weighed in across 2 answers
Membran lipid : In liver disease- there is alteration in the membran lipids in the rbcs. This causes abnormalities of the rbc's membrane causing remodeling in spleen and formation of acanthocytes.
Answered 1/30/2013
5.3k views
Change in lipids: The liver is responsible for general metabolism in the body, and the plasma membrane has a complex collection of lipids that are responsible for its "fluidity" and shape. It is believed that the apolipoproteins are abnormal in liver disease and cause fragility of the rbc membrane causing fragmentation and formation of acanthocytes. See also: http://en.Wikipedia.Org/wiki/acanthocyte.
Answered 7/7/2015
5.3k views
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