Can oxycodone ruin your heart?

Not particularly: Opioid abuse can do many, many things, but ruining your heart is not usually among them. There are rare cases of pulmonary edema, which can look like heart failure clinically, that are associated with opiates, but most cases occur with heroin use rather than prescription drugs, although these are also reported. These cases involve the lungs directly though, and not heart failure.

Consult: Please consult your physician to obtain clear instructions on side effects and when to take your medications. Your health status, such as heart disease, can impact side-effects of medications. Oxycodone is a potent narcotic and should never be taken without a prescription, or with alcohol or with other sedatives. Keep oxycodone bottles or pills out of view.