A member asked:

Can you tell me what the significance is of spindle cells being found in a cervical smear test? i have had colposcopy and biopsy, awaiting results.

2 doctors weighed in across 2 answers

Confusing word: 'spindle cell' is used by pathologist to signify shape of cells - tapering at both ends. They usually refer to connective tissue cells. 'spindle' shaped cells are also seen in certain tumor types derived from connective tissue, in a pap smear, they are probably refering to cervix cells that have assumed that shape. More important is the grade - high grade, low grade, etc.

Answered 1/23/2013

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Variable.: If the final interpretation is negative for malignant cells, you are ok! as highlighted in one of the replies 'spindle' cells just reflect the shape of cells, which may be benign or malignant (and may be epithelial or stromal from deeper tissue). If malignant, usually it is keratinizing squamous cell carcinoma with 'fiber' cells. Other malignant causes are very rare (e.g. Sarcomas, melanoma, mmt ).

Answered 3/26/2013

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