HD and Triple Repeat: With a 31 repeat allele, you still have a 50% chance of passing the allele to an offspring , and, as you know, the number of repeats often expands with meiosis and can mutate post meitotically. Disease is associated with an expansion>35 repeats, and the severity of the disease correlates with the length of the mutation passed on. In one study, 75% of "short" alleles expanded to threshold lengths.
Answered 3/12/2013
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