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A member asked:

Can you have lupus if your ana come back negative?

A doctor has provided 1 answer
Dr. Larry Greenbaum answered

Specializes in Internal Medicine - rheumatology

Unlikely, but...: The ANA is a very sensitive test, so it tends to have too many false positives, rather than false negatives. Textbooks talk about lupus with negative ANA results, but i suspect this is only a tiny percentage of lupus patients. Sometimes other labs or procedures can be helpful. Speak to your doctor.

Answered 6/10/2014

5.4k views

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ANA+ (1:160 homologous), all other titers NEG (Lupus, RA, vasculitis, etc) Rheum thinks seroneg RA. Morning stiffness, joint/spine/SI pain. Possible?

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What could cause ANA positive spec pat. 1;640. I am seeing a rheumtoligist. No answers! serum protein ok. Lupus neg. Up back pain. Cbc ok. Urine ok.?

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I had a biopsy for localized Discoid Lupus. It came back positive. Blood work shows 1:80 ANA, negative for DS-DNA and negative for SM Antibody. Should I be concerned that I also have SLE?

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A member asked:

Had lower back pain since 2018, I have done MRI's, Physical Therapy, EMG, etc. All normal. ANA was tested to rule out Lupus, the ratio came back borderline, ~6 months later with the worse pain, my test is negative. Why? Could it still be Autoimmune?

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A member asked:

My temp after i get to work is 99.1-99.4 . Evening and over night normal. I am ANA +1:640 spec pattern. High sed rate. Cbc ok. Metabolic ok. Serum protein ok. Lupus panel neg. Up back pain 1yr. Mri ok?

A doctor has provided 1 answer

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I have had multiple positive ANA and they do the next step tests to check for lupus and it comes back negative. Why do they keep checking my ana?
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