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Montrose, CO
A 66-year-old female asked:

Is 25mg diphenhydramine hci at night harmful? what about long term use? i'm weaning off xanax, (alprazolam) & this helps me get to sleep. i'm 66 & in good health. getting off xanax (alprazolam) has helped my memory!

2 doctor answers4 doctors weighed in
Dr. Pamela Pappas
Psychiatry 43 years experience
Talk w/doctor: On this question, you need to talk with your own doctor. It's very true that xanax (alprazolam) can interfere with memory, because it's a sedating substance. Weaning off very gradually can be helpful to you in this way. However, in some people Diphenhydramine can also interfere with memory and cognitive function because of its anticholinergic features.
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 33 years experience
Benadryl (diphenhydramine): 25 mg. Is low dose, if it is helping u, but u need to gradually wean yourself off of it in the next few weeks, and follow up with your doctor meanwhile.
Last updated Jun 25, 2014

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