My mom was diagnosis with tubulo-lobular breast cancer nottingham score grade 2. tubule formation was graded 3, with very little tubules . how can this be.?

Mostly lobular: If the tumor is mostly lobular with very little tubule formation it would be graded 3 in terms of tubule formation. The overall grade would still be 2 since the nuclei are usually small sized and the mitotic rate low. These tumors usually have a good prognosis if they are under 2cm and a single focus.

Prognosis: Tubular breast cancer or lobular breast cancer or tubulolobular that's a combination have excellent prognosis. Usually they are endocrine responsive and in majority of them, chemotherapy can be avoided. Pathological description can be confusing but bottom line is they have very good prognosis after proper surgery and completion of adjuvant therapy.

I ma having difficul: I am not sure what your question really is. The description that you have given is what is commonly reported by a pathologist after reviewing the cancer cells under the microscope. This has very little if any significance in terms of prognosis or treatment. I would be more concerned aboutt stage of this breast cancer and about hormones receptors and her2 receptor status. These are more relevant