Does ortho cycles make you gain weight?

Possibly: Sometimes yes, usually no. They all can to some degree.

Possibly 2: Ortho makes several birth control pills, but pills can be discussed in general. All pills in the US except one have ethinyl estradiol, a synthetic estrogen 30x more potent than natural estrogens. The common side effects like weight gain come from the progesterone-like compounds in the pill called progestins.These side effects like weight gain, irritability, acne, are different for different pills.