A member asked:

Gi advised me to take 50 gm of benadryl & 1000mg of tylenol (acetaminophen) prior to next remicade infusion to prevent post reaction leg ache i had last. any advice?

2 doctors weighed in across 2 answers

Do it: It's recommended to take those to prevent the common reactions of rash and fever from biologics like remicade (infliximab).

Answered 1/8/2013

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Remicade (infliximab): The recommendation is not too unusual. 50 milligrams(not grams) of Benadryl (diphenhydramine) and one thousand milligrams(1 gram) of Acetaminophen to reduce side effects of the interferon is used by some physicians. For many patients the muscle aches & pains settle down after the 1st month or so of therapy.

Answered 6/24/2014

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