Would it be possible for depression to lead to cardiovascular diseases?

Indirectly?: Depression can lead to poor life choice which could predispose you to CAD in the future like smoking, over eating, not exercising. There have studies which show patients who develop depression after heart surgery have higher complication and death rate. I think the same holds for heart attacks too. I put most of my patients on antidepression meds after surgery.

Yes and vice versa: Anxiety, depression and certainly personality traits, such as type a can contribute to increased risk and worse prognosis for cardiovascular disease (cvd) which can increase risk for comorbid depression and anxiety. For further discussion see: http://cpancf.Com/articles_files/cardiovasculardiseasemoodcognitive.Asp.

Dep.: It can go both ways also treatment for depression can affect the cardiovascular system.

Possible: There is so called broken heart syndrome-which is a temporary heart condition brought on by stressful situations, such as the death of loved one etc. The condition was originally called takotsubo cardiomyopathy. Today, it's also referred to as stress cardiomyopathy, stress-induced cardiomyopathy. Yes, it can happen vice versa-just like my other colleagues reffering here.

Yes, absolutely: Yes, this can happen not only for psychosocial reasons, but also from mechanistic ones. Research studies show that depressed people have exaggerated platelet reactivity -- and this can also lead to vascular damage and thrombosis. Also, depressed people have higher inflammatory cytokines that play a role in atherosclerosis. Other inflammatory markers like c-reactive protein are elevated too.