A member asked:

Can extra strenght benadryl (diphenhydramine) cream cause tiredness ?

A doctor has provided 1 answer
Dr. Tracie Leonhardt answered

Specializes in Emergency Medicine

Yes: Benadryl (diphenhydramine) a is an antihistamine and can cause drowsiness. Histamine is a neurotransmitter that excites or makes the system alert - so something that blocks it can make the system drowsy.

Answered 6/24/2014

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Is Benadryl (diphenhydramine) cream safe for 2 year olds?

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