Do you have to have a biopsy to diagnose neuroblastoma?

Usually: The diagnosis is usually suspected by age of patient, symptoms and imaging results. However it is generally confirmed by a pathologist who looks at the biopsied tissues under a microscope. Neuroblastoma tumors have a specific look under the microscope and are often described as small, blue and round cells.

Yes: There are many prognostic factors which dictate treatment and prognosis for patients with neuroblastoma. These include histologic, biologic, and genetic factors related to individual tumors. The only way currently to obtain this important information is via tissue analysis. In cases where bone marrow is involved, the diagnosis can be established this way. Otherwise, tumor biopsy in necessary.

Yes: The purpose of the biopsy is to confirm the nature of the mass. If the biopsy is positive then chemotherapy can be started and a port or broviac inserted to facilitate administration of the chemo. Oftentimes the mass cahn be rermoved at toime of biopsy. If too large or involving other organs a second look procedure can be done after 3-4 rounds of chemo.