I've been taking adderall for 10 years (30 mg 2xday). what are the long-term effects of central nervous system stimulants?#nqlu i'm 57 & in addition to adderall, take zoloft (50 mg), armour thyroid (90 mg), bystolic (10 mg), and tamoxifen (20 mg).

This : This is an important question that, unfortunately, still has no unambiguous answer. I have posted a link to a summary of a review article by p. Hazell that has been recently published in current opinion of psychiatry. As the author pointed out, two studies and one published report attempted to answer this question. One was favorable, one found no benefit and one found harm from long term stimulant use. The author of this paper concludes that more studies are needed in order to answer this question.

Usually not many: Some doctors recommend having "holidays" from stimulants, for times when not having the best concentration and focus might not matter as much - like weekends, vacations etc. There is little or no evidence that long-term medicinal stimulants taken as prescribed cause any significant damage to the cns, although sleep disturbance/anxiety and hopelessness (depression) may be related. Talk to your doc.