A member asked:

How does cirrhosis cause liver cancer? i have liver cirrhosis, and ive read that increases my risk of getting liver cancer. how does that work?

3 doctors weighed in across 2 answers

Cell : Cell growth and death is always occurring all over our body, including liver cells. Cirrhosis results in disrupted anatomy of the cells of the liver. Over time this affects dna. Alterations in dna can result in mutations of genes that make liver cells. When mutations occur there is a risk of a mutation involved in cell programming, to include programmed cell death, which is supposed to occur. When the genes that program the liver cell to die fail to work, the cell can multiply/grow out of control, which is what cancer is. This growth requires a lot of energy and nutrients, supplied by blood. In time, this growth overtakes the body's ability to compensate for the increase in nutrient requirements and death ensues.

Answered 10/3/2016

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Nobody knows fully: Cirrhosis is both a degenerative and an inflammatory disease. The nodules of abnormal liver tissue are growing abnormally because they are inflamed by whatever caused the cirrhosis (hep viruses, alcohol, auto immune disorder etc.). Chronic inflammation can lead to malignant transformation, and does in 10%+ of cases of long-term cirrhosis. Reducing the inflammation, when possible, is what helps.

Answered 4/14/2017

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