Chromosome tests: For people with cml, bone marrow chromosome studies (karyotype) often show the philadelphia chromosome (a chromosome #22 that is shortened because its distal end is transferred (translocated) to chromosome 9. Antibody (gleevec) to the translocation protein is helpful and bone marrow transplant is a form of gene therapy that provides cells with normal chromsomes.
Answered 7/17/2013
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Pcr-FISH-karyotype: There are 3 main types of genetic tests. The old standard is to take a blood sample from the hip (marrow) and grow cells to look at all the chromosomes (karyotype). It is a 'broad strokes' look but not as sensitive as the others. A fish test looks at blood cells with 'probes' to the known genetic changes (moderately sensitive) and a PCR test is a 'molecular' test of the dna (very sensitive).
Answered 1/12/2015
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