What are the potential risks of a pronounced (enlarged) thyroid?

Usually none!: Usually a sign of both hypothyroidism, or grave's disease, which causes overactivity. However, both thyroid nodules and malignacy can do this. You need some blood tests, and ultrasound of your thyroid, and perhaps a thyroid biopsy, if indicated. Women are more prone to goiters, usually caused by autoimmune issues!

Cancer is one risk: There are a lot of possibilities. Cancer is a risk, but most people with goiter do not have cancer. First, is your thyroid overactive, underactive, or normal? Second, what does it feel like? Smooth: maybe autoimmune thyroid disease (hashimotos, graves), which runs in families. Lumpy/hard: more of a concern. You may need an ultrasound directed needle biopsy, best done by an endocrinologist.