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A 35-year-old member asked:

what ratio of pro-collagen molecules are abnormal in type 2 osteogenesis imperfecta?

1 doctor answer1 doctor weighed in
Dr. David Rosenfeld
Pain Management 27 years experience
See below: Osteogenesis imperfecta (oi) is disorder of congenital bone fragility caused by mutations in the genes that codify for type i procollagen (ie, col1a1 and col1a2).

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A 21-year-old member asked:

What collagen strengthening agents, other then vitamin C are there?

2 doctor answers3 doctors weighed in
Dr. Scott Bolhack
Wound care 35 years experience
Collagen: Collagen is a vital part of the connective tissue of the body. It's main component is of protein. Eating a healthy diet with adequate protein would be the most important thing that you can do to insure healthy healing. Recommendations for specific micronutrients are easy to make by looking at the components of collagen or how it is made, but evidence of specific benefits would be lacking.
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A 46-year-old member asked:

Are certain ethnic groups at higher risk of osteogenesis imperfecta?

2 doctor answers3 doctors weighed in
Dr. William Banks Hinshaw
Obstetrics and Gynecology 43 years experience
In general, No....: .... But certain very small ethnic groups in Africa and canada have been observed to suffer an increased incidence.
A 34-year-old member asked:

Can osteogenesis imperfecta be detected prior to birth?

2 doctor answers4 doctors weighed in
Dr. Devon Webster
Medical Oncology 22 years experience
Sometimes: It depends on the type of oi. If a parent has oi, and the genetic mutation they carry has been identified, the fetal dna can be checked for the same mutation. This is done through amniocentesis and chorionic villus sampling. Sometimes fetal ultrasound can show changes of oi in severe cases.
A 32-year-old member asked:

What is the difference between osteoporosis and osteogenesis imperfecta?

2 doctor answers9 doctors weighed in
Dr. James Chu
Endocrinology 25 years experience
OI collagen disease: Osteogenesis imperfecta (oi) is a congenital disorder of collagen (important component of bone). Oi is present at birth, and leads to repeated fractures, starting in childhood. There is no consistent treatment to prevent fractures in oi. Osteoporosis refers to an acquired state of fragile bones, most commonly occurring in post-menopausal women. Many therapies can reduce osteoporosis fractures.
A 31-year-old member asked:

Why does excessive perspiration occur in osteogenesis imperfecta?

1 doctor answer3 doctors weighed in
Dr. Devon Webster
Medical Oncology 22 years experience
Thin skin: Oi affects bones and collagen, which makes up a large part of the skin. People with oi have thin skin and as a result, higher normal body temperatures (by 1-2 degrees). They can be more sensitive to both heat and cold, and need to sweat more to reduce their body temperature.

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Last updated Oct 4, 2016
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