Doc my wife is pregnant and is having recurrent uti since beginning of second trimester...all the urine cultures from past 3 months show ecoli 10 rais?

See ID specialist: Possible causes of recurrent UTI are any kidney stones, cysts, any structural problems. Other possibilities are incompletely treated infection of if the organism is resistant to the antibiotic being used. Her obstetrician can certainly guide in the right direction but you may need to see infection diseases specialist and or urologist.