On average what is the success rate over 3 cycles of iui for couples with unexplained infertility?

It depends: It depends on the age of the female partner and what fertility drugs are being used.

It depends...: It is most definitely dependent on age and duration of infertility. However, it also depends on what ovulation medications are being used. One can predict a pregancy rate of 6-9% per month with Clomid (clomiphene) and 12% for hmg/fsh in an unselected group of couples with unexplained infertility. Good luck!

Average is 3-4 trys: 6 cycles of IUI on injectable medications costs around the same as one cycle of ivf. One takes 6+ months and ivf takes 6 weeks. Here is the "rub". 6 cycles of IUI is not as successful as 1 cycle of ivf. So it is a choice. By doing iui, you "gamble" that it works in 2-3 attempts and save money; but if not, than ultimately it costs more because when IUI does not work, you have to go to ivf.