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A member asked:
Identify the mode of action of pyridostigmine to improve muscle strength in myasthenia gravis?
A doctor has provided 1 answer
Synaptic cleft: Pyridostigmine inhibits acetylcholinesterase in the synaptic cleft by competing with acetylcholine for attachment to acetylcholinesterase, thus slowing down the hydrolysis of acetylcholine, and thereby increases efficiency of cholinergic transmission in the neuromuscular junction and prolonges the effects of acetylcholine, what ultimately improves the strength of the muscle.
Answered 3/20/2015
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