Prescribed prednisone at 60mg- 3 days, 40mg- 3 days, 20mg 3 days. today is the first day at 20mg and already the pos effects are gone. why so quickly?

Your level of....: Your level of inflammation must be high. The taper is fairly rapid as well. Taking an NSAID may help, but the co-use of another anti-inflammatory other than steroids, depending on diagnosis may help. Methotrexate is the most common steroid sparing agent I use in rheumatology patients with arthritis or connective tissue disease!