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A 23-year-old member asked:

Why do lupus tests sometimes come back negative?

2 doctor answers5 doctors weighed in
Dr. Morris Westfried
Dermatology 47 years experience
Not 100 %: There re several tests for lupus ana, double stranded dna and none of these tests is 100 per cent reliable for the diagnosis of lupus. A similar situation occurs in rheumatoid arthritis where there seedless negatives as well as false positives. If there is akin involvement a skin biopsy for direct exam as well as immunoflourescence can help with diagnosis.
Dr. John Goldman
Rheumatology 56 years experience
Depends: Which tests are you thinking of? Certain tests can improve because you have a chance that the lupus activity is down. Sometime tests are negative because of laboratory error. Sometimes blood tests are negative because you have also developed certain blocking substances that can interfere with the test. This all depends on your status, lupus activity, immunologic responses, etc.

Similar questions

Brownsburg, IN
A 20-year-old female asked:

Is it possible to have lupus but come back negative on the test or is the test the only way to tell?

1 doctor answer1 doctor weighed in
Dr. Richard Zimon
Internal Medicine 60 years experience
Yes: the test may be negative in early LUPUS and may give false POSITIVES as well... No test is 100% "foolproof" ANTI-NUCLEAR antibodies and if positive a certain TYPE of anti-nuclear response may be helpful! Hope this info helps! Dr Z
Last updated Oct 23, 2017


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