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A member asked:
Pre-renal acute renal failure may occur without systemic hypotension in patients taking nsaid or acei , why ? i just do not get it ?
A doctor has provided 1 answer
Effect blood flow: Nsaids interfere with prostaglandin production in the kidney , some of which may cause blood vessels to dilate. Blocking the prostaglandin production causes the vessels to constrict and decreases blood flow to the kidney. Acei inhibit angiotensin ii production this allows the efferent arteriole to dilate, lowering the hydrostatic pressure in the glomerulous and decreasing kidney function.
Answered 9/28/2016
5.5k views
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