Been on provigil for narcolepsy for 10yrs are then any studies for possible problems with long term use?

Unlikely: Most patients on Provigil do very well without any long-term problems. Always prudent to periodically check liver fnctns and blood count just in case, but unlikely any issues. Also, positive is fact that tolerance with Provigil is rather uncommon, so doseage can stay stable.

Usually not: Overall a very safe medication, long term usage has not been fully studied. The thought is that it works through Dopamine pathways, so some long term effects can be on this system. Neurologic function and mood disturbances have been reported side effects of long term usage.