Is there a cure for systemic lupus erythematosus (sle)?

Yes, but: Theoretically, a "reboot" of the immune system, ie a bone marrow transplant, could cure lupus, but this is risky enough that it is very rare. The best treatment includes close monitoring with one's doctor and rheumatologist.

SLE treatment: Systemic lupus erythematosus (sle) is a long-term autoimmune disorder that may affect the skin, joints, kidneys, brain, and other organs. There is no cure for sle. The goal of treatment is to control symptoms.