A member asked:

Why hydroxychloroquine is effective in treating systemic lupus erythematosus?

A doctor has provided 1 answer
Dr. Thomas Namey answered

Specializes in Rheumatology

It is magic?: 1the use of anti-malarials in autoimmune diseases was accidentally discovered in treating wwii vets for malaria. Those with RA improved. Chloroquine and ho-q were tested in sle, with very positive results. In the early 80's canadian researchers definitively showed fewer sle flares with ho-q. It is considered the rx of first choice for :sle. We now understand more of the mechanisms, but not all.

Answered 4/18/2019

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