A member asked:

I do not enjoy life at all. i have been on different combinations of anti depressants for 17 years. every day is a struggle. not sure i can go on?

5 doctors weighed in across 2 answers

See below: I"m sorry you're going through this. Look at things that worked for past 17 years. Find a psychologist or a mental health provider to help you figure out issues that might be causing your feelings. If you're having thoughts of self-harm that are overwhelming, go to the nearest emergency room or dial 911. National suicide prevention hotline 1-800-273-talk. Good luck!

Answered 12/9/2013

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Treatment resistance: Some depressions r tougher than others--don't give up there are many approaches u probably haven't tried--get another opinion-- ECT , maois, different combinations of antidepressants antipsychotics mood stabilizers etc--hang in there & try other treatment approaches.

Answered 1/2/2015

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