A member asked:

Hi, for the alzheimer's disease.how to choose btween galantamine (galantamine hydrobromide) 4mg bd or memantine 5mg?

5 doctors weighed in across 2 answers

Complementary drugs: Galantamine (galantamine hydrobromide) & memantine work through different mechanisms and are complementary, not an either-or choice. The two doses you mention are both starting doses, not maintenance doses. Onset of action of either drug may be as long as 3 months. It is better not to initiate both drugs simultaneously but wait until patient achieves maintenance dose is achieved before introducing the other.

Answered 12/28/2012

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Dr. Maureen Nash answered

Specializes in Geriatric Psychiatry

Not equivalent: Galantamine (galantamine (galantamine hydrobromide) hydrobromide) is in a different class of medicines than memantine so they are not equivalent. The combination of memantine and a cholinesterase inhibitor such as galantamine (galantamine hydrobromide) is used in moderate to severe dementia to decrease behavioral symptoms. The combination appears to work better than either alone.

Answered 5/3/2016

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