Do patients with knee replacements. need to premedicate?

Yes: That is a short and not well proven answer;but a safe one.

Yes is best: The american academy of orthopaedic surgeons has made a consensus statement regarding this topic and can be reviewed on their website at www.Aaos.Com. Their long treatis on this topic leaves even a seasoned joint specialist like myself without a strong recommendation for or against its use in general terms do to the lack of overwhelming evidence supporting or rejecting it's use. Me, i'd take um.